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Various studies and observations show that a “one size fits all” dietary recommendation for weight management is questionable. The focus on personalized nutrition has become increasingly popular and the inclusion of genetic variants for personalized recommendations has emerged over the last two decades and is growing. Certain popular genetic testing companies, including some that sell direct-to-consumer (DTC) genetic tests, make dietary recommendations for macronutrient distribution based on your gene results. The regulation of weight gain and weight loss is complex. In addition to energy intake and expenditure, physiological parameters such as detoxification, inflammation, glucose and insulin balance, hormone balance, and central nervous system regulation all play a role in body weight management. Signals of hunger and satiety are transmitted from fat tissue, muscles, and the gastrointestinal tract to the brain. All of these are impacted by genetic variation, environment, lifestyle habits like sleep, exercise, stress as well as cultural influences. Weight loss advice based on macronutrient distribution only does not consider the nutrigenomic impact that micronutrients have on gene expression. The report that GenetixCoaching provides, incorporates various pathways involved in all aspects of weight management and is not limited to energy metabolism.
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